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Volume 5, Issue 6 (Suppl) J Mat. Sci.
ISSN: 2321-6212 Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13TH INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
Modeling of nanoparticle surface charge for targeting glioblastoma
Joao Sousa, Ana Miranda, Tania Cova, Maria Mendes, Carla Vitorino and Alberto Pais
University of Coimbra, Portugal
Glioblastoma Multiforme (GBM) is an aggressive brain tumor with poor prognosis, mainly because standard treatment
is not always effective enough in reaching tumor cells. Blood-Brain Barrier (BBB) is pointed out as one of great
challenges in this field. Considering the negative charge of BBB surface and its restricted permeability to small compounds,
positively-charged nanoparticles have been developed to facilitate the transport of drugs through the BBB. This work aimed
at studying the interaction of different cationic surfactants used in Lipid Nanoparticle (LN) formulations with BBB, using
atomistic simulations. Surfactants incorporating natural structural motifs, specifically serine, were chosen instead of the
conventional synthetic surfactants, due to the lower cytotoxicity and higher biodegradability, thus being environmental
friendly. Molecular dynamics simulations were performed on 4 systems containing different serine-based surfactants, two of
them are monomeric (16SerTFA and 12SerTFA) and the other two are dimeric ((12ser)2CON12 and (12ser)2N5), in a fully
hydrated palmitoyloleoylphosphatidylcholine (POPC) lipid model, intended to mimic cell membranes of both the BBB and
tumor. The systems were evaluated in terms of effects induced by the surfactants in this type of membranes and rationalize the
interactions at molecular level. The results showed an integration of all surfactants into the POPC membrane. Longer chain
length surfactants tended to induce the highest membrane stabilization, as evidenced by 16serTFA. Conversely, the dimeric
(12ser)2CON12 led to the greater disturbance in the membrane structure, probably due to bridging phenomena. This may
anticipate a better BBB cross ability of LN containing (12ser)2CON12. Overall, this computational study suggests the viability
of cationic serine-based surfactants as appealing compounds in LN formulations for targeted GBM therapy.
References
1.F Pourgholi, M Hajivalili, J N Farhad, H S Kafil, M Yousefi (2016) Nanoparticles: Novel vehicles in treatment of Glioblastoma, Biomedicine & pharmacotherapy=Biomedecine &
pharmacotherapie; 77: 98-107.
2.D K F Santos, R D Rufino, J M Luna, V A Santos, L A Sarubbo (2016) Biosurfactants: Multifunctional Biomolecules of the 21st Century, International journal of molecular sciences;
17: 401.
Biography
Joao Sousa is a Faculty of Pharmacy at University of Coimbra, Portugal. He has published numerous research papers and articles in reputed journals and has
various other achievements in the related studies. He has extended his valuable service towards the scientific community with his extensive research work.
Joao Sousa et al., J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-009