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Volume 5, Issue 6 (Suppl) J Mat. Sci.
ISSN: 2321-6212 Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13TH INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
Oligopeptide-based polymers targeting human antigen R (HuR) for the treatment of psoriasis
Ai-Li Shiau
National Cheng Kung University, Taiwan
Psoriasis is a common chronic inflammatory skin disease, characterized by abnormal differentiation and proliferation of
keratinocytes, angiogenesis and infiltration of inflammatory cells that secreteTh1 andTh17 associated cytokines in the skin
lesion, such as TNF-α, IL-17 and IL-20. Although mRNAs that encode cytokines are short-lived mRNAs in eukaryotes, the pre-
mRNAs, which contain AU-Rich Elements (AREs) in their 3’-untranslated regions, are recognized and stabilized by Human
Antigen R (HuR), an RNA-binding protein, for post-transcription. Previous studies have suggested that HuR is involved in
the stabilization of mRNAs in the psoriatic skin. HuR binds to and regulates IL-20 mRNA and relocalizes to the cytoplasm of
psoriatic keratinocytes. Furthermore, HuR can bind numerous transcripts involved in the pathogenesis of psoriasis. Therefore,
HuR may be a potential therapeutic target for psoriasis. In the present study, we tested several novel oligopeptides that targeted
the RNA binding site of HuR as therapeutic agents for psoriasis. A mouse model of imiquimod (IMQ)-induced psoriasis-like
dermatitis was generated in BALB/c mice by daily topical application of IMQ cream on the ear from days 0 to 9. The mice
were treated with oligopeptides from days 5 to 10. The pathological features of psoriasis were scored daily using the thickness
gauge and clinical Psoriasis Area and Severity Index (PASI). We found that the oligopeptide JS-1 could significantly ameliorate
psoriasis pathogenesis in a dose-dependent manner. The oligopeptide affected the HuR downstream signaling pathway.
Collectively, this study may provide an alternative therapeutic strategy for psoriasis.
Biography
Ai-Li Shiau is a Distinguished Professor of the Department of Microbiology and Immunology and Institute of Clinical Medicine, College of Medicine, National Cheng
Kung University, Taiwan. She currently serves as the Head of the Department of Microbiology and Immunology, NCKU. She has received her PhD in Molecular
Biology from University of Edinburgh. She has expertise in viral vectors for gene therapy and vaccine applications and published more than 100 papers in peer-
reviewed international journals.
Ai-Li Shiau, J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-009