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Pathology 2018
Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865
Page 78
October 08-09, 2018
Edinburgh, Scotland
17
th
International Conference on
Pathology & Cancer
Epidemiology
A
bdominal aortic aneurysm (AAA) is an abnormal dilatation
in a weakened region of the main abdominal blood vessel.
Approximately 5% of men over 65 years of age have an AAA.
Prevalence of AAA is increasing rapidly in an aging population
and becoming increasingly common in women. Patients with
AAA present an increased risk of major cardiovascular events
such as stroke andmyocardial infarction, and AAA is amongst the
leading 15 causes of death for people aged >60 years. Surgical
intervention is currently the method for AAA correction but is
associated with significant peri-operative mortality and currently
there is no medical cure for AAA. Detailed information regarding
the aneurysms is a prerequisite for targeted drug development
for AAAs and currently it is still limited even after numerous
genetic studies conducted in the past. Analysis of disease-
state epigenome when compared to the normal epigenome
provides a valuable foundation to study the regulation of gene
expression crucial to the development of complex diseases.
DNA methylation and histone modifications are two important
epigenetic mediators of transcriptional repression. Several lines
of evidences suggest an important role of altered epigenetic
status in inflammation, proliferation and remodelling processes,
which are also associatedwith the development of AAA indicating
that epigenetic changes are crucial in the development and
progression of AAA. In this study, an over view of evidences of
the role of epigentic mechanisms in AAA pathology is presented.
smriti.krishna@jcu.edu.auRole of epigenetic mechanism in the pathology of abdominal
aortic aneurysm
Smriti M Krishna
and
Jonathan Golledge
Queensland Research Centre for Peripheral Vascular Disease - James Cook University, Australia
RRJMHS 2018
Volume: 7