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Pathology 2018 Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865 Page 82
October 08-09, 2018
Edinburgh, Scotland
17th International Conference on
Pathology & Cancer
Epidemiology
Background: Gastric cancer is one of the leading causes
of cancer related death worldwide. Many patients have in
operable diseases at diagnosis or have recurrent diseases
after resection with curative intent. Gastric cancer is seperated
anatomically into true gastric adenocarcinoms and gastro
oesophageal junction adenocarcinomas and histologically
into diffuse and intestinal types. Gastric cancer should be
treated by team of experts from different discipline. Surgery
is the only curative treatment for locally advanced diseases.
Chemotherapy is usually implemented in combination with
surgery. In metastatic diseases, outcomes are poor with
median survival being around one year. For the first time in
Herat province of Afghanistan I decided to have a research on
gastric cancers. Since there was no pathology laboratory in
the past, no data is available about prevalence and incidence
of this diseases. I collected the data and related possible
causes of gastric cancer in my cancer diagnostic center, in
order to inform the community about this dangerous diseases.
Unfortunately in our country most of patients diagnose in late
stages of cancer because of lack of facilities and awaraness of
diagnostic methods.
Objective: To evaluate the histopathologic types of gastric
cancer and related risk factors in Herat city.
Methods: This research is a descriptive study (based on
existing data) or cross sectional study. The study population
consists of 152 gastric biopsies from the patients who were
suffering form gastric disorders. Endoscopically mucosal
resection (biopsy) is taken by endoscopists and referred to
Firooz pathology laboratory for diagnosis. The research data is
from 01/01/2015 to 01/01/2017.
Materials: All tissues were excised by endoscopy as mucosal
resections (biopsies). The diagnosis of the tissue samples
were according to histologic prepared and stained slides (H&E)
after standard histotechnology.
Results: In this study, 152 biopsies were assessed. 137 patients
diagnosed gastric cancer, among them 95 (69.2%) were males
and 42 (30.7%) females, 45.26% of cancer patients aged over
60 years old. In (71.05%) of biopsies revealed intestinal type
adenocarcinoma. (11.8%) of patients the biopsies showed
diffuse type carcinoma. Dysplasia were noted in (6.57%) of
biopsies. Finally (2.70%) of biopsies revealed atrophic gastritis
and (0.65%) of cases revealed lymphoma NHL. In 49.6% of
cases the tumors had proximal location and in 50.44% of cases
the tumor had distal location. Low grade adenocarcinoma were
seen in 22.6% of cases, moderately differentiated were seen in
19.7% of cases and poorly differentiated were seen in 57.7% of
cases. In this study 41.6% of cases revealed Helicobacter pylori
in gastric mucosa. Patients who diagnosed gastric cancer did
not use alcohol and Tobacco, most used meat in their daily diet.
Conclusion: By considering this fact that gastric cancer is a
dangerous disease specially in undeveloped countries like
Afghanistan and killsmany people, it ismandatory for physician
to diagnose gastric cancer in onset and early stages, in order
to survive patients. Acording to our study most of referring
patients (57.7%) suffered from Grade III adenocarcinoma and
diagnosed poorly differentiated adenocarcinoma during there
first endoscopy and histopathologic examination and the mean
age for gastric cancer was 57.8 therfore, it is recommended
for doctors to consider abdominal discomfort and gastric
disorders as a serious problem and do necessary investigative
methods especially in ages above 45 years with special
emphasis on early diagnosis of disease inorder to reduce and
decrease the death rates.
Histopathologic evaluation and prevalence of gastric
cancer in Herat Provnice of Afghanistan for the first time
Haroon Firooz
Herat University, Afghanistan
RRJMHS 2018
Volume: 7