16 / 21
Page 50
Euro Pharma Chemistry & Future Pharma 2019
Volume 08
Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on
Joint Event
4
th
Pharmaceutical Chemistry Conference Future Pharma
Biodegradable injectable in situ depot-forming PLGA for controlled release of paclitaxel
Mohammad Sadegh Amini-Fazl
University of Tabriz, Iran
T
he purpose of this study is to develop Cremophor® EL-free in situ depot forming loaded with paclitaxel
(PTX), able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor
®
EL. Injectable in situ-forming implant have received considerable attention as localized drug delivery systems.
Here, we examined a poly-(DL-lactic-co- glycolic) acid (PLGA) as an injectable drug depot for paclitaxel
(Ptx).
In vitro
experiments showed that Ptx was released from PLGA over the course of more than 30 days.
The release profile shows a slow diffusion-controlled phase, followed by a more rapid degradation-controlled
region. Two semi-empirical mathematical models (Power law and Peppas) were applied to drug release data
in order to elucidate release mechanisms and kinetics. In order to confirm the results of drug profile release,
study of the polymer degradation process for the direct determination of the monomer(s): lactic acid (LA) and
glycolic acid (GA) with a new HPLC method is proposed.
Pharmaceutical Analysis 2019, Volume 08