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Volume: 08
Research & Reviews: Journal of Medical & Health Sciences
Page 28
Notes:
Diabetes Congress & Cancer summit 2019
December 04-05, 2019
conferenceseries
.com
December 04-05, 2019 | Tokyo, Japan
Asia Pacific Conference on
Diabetes Oncology
Teresa Cano de Terrones et al., RRJMHS 2019, ISSN: 2319-9865
Mulinum crassifolium Phil; two new mulinanes, gastroprotective fibromyalgia activity and metabolomic
analysis by UHPLC-orbitrap mass spectrometry
Teresa Cano de Terrones
2
, Carlos Areche
1
, Ronald Fernandez-Burgos
1,2,
Mario Simirgiotis
3
, Olimpo García-Beltrán
4
, Jorge Borquez
5
and Beatriz
Sepulveda
6
1
University of Chile, Chile
2
National University of San Agustín, Peru
3
Universidad Austral de Chile, Valdivia
4
University of Ibagué, Carrera
5
University of Antofagasta, Chile
6
Universidad Andrés Bello, Chile
M
ulinum crassifolium Phil. (Apiaceae) is an endemic shrub from Chile commonly used as infusion in traditional
medicine to treat diabetes, bronchial and intestinal disorders and stomach ailments, including ulcers. From the EtOAc
extract of this plant, the new mulinane-type diterpenoids 3 and 5 were isolated along with three known diterpenoids. e
gastroprotective e ect of the infusion of the plant was assayed to support the traditional use and a fast HPLC analysis using
high resolution techniques was performed to identify the bioactive constituents. e EtOAc extract and the edible infusion
showed gastroprotective e ect at 100 mg/kg in the HCl/EtOH induced gastric ulcer model in mice, reducing lesions by 33%
and 74%, respectively. Finally, a metabolomic pro ling based on UHPLC-ESI-MS/HRMS of the edible infusion was performed
and thirty- ve compounds were tentatively identi ed including quercetin, ca eic acid, apigenine glucoside, p-coumaric
acid, chlorogenic acids, and ca eoylquinic acids, which have been associated previously with gastroprotective and antiulcer
properties. is scienti c evidence can support the contribution of polyphenols in the gastroprotective activity of the edible
infusion of this plant, and can validate at least in part, its Ethnopharmacological use.
Biography
Teresa Cano de Terrones has her experience in evaluation and passion to improve health and wellness research as a teacher and researcher. Its evaluation and
research model is open and contextual based on receptive constructivists who create new ways to improve medical c are. She has built this model after years of
experience in research, evaluation, teaching and administration. Its methodology is based on the evaluation of different plant species, which is techniques used
by previous generations of evaluation: measurement, description and judgment. It allows the pluralism of values. This approach responds to all interested parties
and has a different way of focusing. Advice in masters and doctorate in the areas: molecular biology, chemistry of natural products, and its application in the field
of medicine, bioremediation, and nanoparticles obtained from plant extracts with sales of noble metals.
tcanefa@gmail.com