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Volume: 08
Research & Reviews: Journal of Medical & Health Sciences
Page 31
Notes:
Diabetes Congress & Cancer summit 2019
December 04-05, 2019
conferenceseries
.com
December 04-05, 2019 | Tokyo, Japan
Asia Pacific Conference on
Diabetes Oncology
Fatemeh Babaie, RRJMHS 2019, ISSN: 2319-9865
A better targeted drug therapy
Fatemeh Babaie
Semnan University of Cellular and Molecular Biology, Iran
A
ntibody drug conjugates(ADCs) currently have substantial limitations. Because they can have unpredictable e ects and
may be unstable, losing their payloads and producing toxicity. So we set out to design more stable and predictable ADCs
by using computer simulations to predict and plan out how the drug payload and antibody can stay linked to each other.
We designed a LEGOlike linker that just clicks a drug payload to any antibody we want. at means we can deliver a drug
speci cally to any tissue that expresses the target of the antibody. Also we used computational docking molecular simulations
to create prototype that could link an antibody and drug payload and mapped the binding sites to determine how liganddrug
pairs would bind to di erent antibodies. We synthesized the various components and showed that when they were incubated
together, they could self-assemble into ADCs, like magnets that nd one another. Inspired by this observation, we named
this approach MAGNET ADCs, which stands for multivalent and a nity-guided antibody empowerment technology. e
MAGNET ADCs could be generated rapidly and did not require modifying antibodies and it showed long-term stability in
plasma, lasting 14 days and showing low toxicity. is technology could be adapted to a variety of therapeutic or diagnostic
uses. We tested MAGNET ADCs in a model for human lung cancer and envisage that the MAGNET-ADC approach can be
extended to a wide range of therapeutic molecules as well as to diagnostics, with potential uses beyond the treatment of cancer.
Biography
Student of cellular and molecular biology, Medical researcher, International degree in genetic engineering, Participated in the 3rd international neuroinflammation
congress and the 3rd international student festival of neuroscience organized by neuroscience department, mashhad university of medical science, Participated in
the 3rd international biotechnology congress of Islamic republic of Iran, Participated in the 3rd international congress on biomedicine2019, Participated in the 8th
International Conference on Women’s Health, Tehran, Iran
mahijk1997@yahoo.com