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Volume: 08
Research & Reviews: Journal of Medical & Health Sciences
Page 30
Notes:
Diabetes Congress & Cancer summit 2019
December 04-05, 2019
conferenceseries
.com
December 04-05, 2019 | Tokyo, Japan
Asia Pacific Conference on
Diabetes Oncology
Majed Bawazeer et al., RRJMHS 2019, ISSN: 2319-9865
In vitro
hepatocellular carcinoma evaluation of different extracts of medicinal plants
Majed Bawazeer
1
, Bathini Thissera
1
, Mallique Qader
1,2
,Ayman Banah
3
, Mostafa E. Rateb
1
, Mohammed Yaseen
1
*
University of the West of Scotland, United Kingdom
C
ancer is a leading cause of death worldwide. According to WHO reports, more than 8.8 million deaths were recorded in
2015. Resistance on chemotherapeutic drugs has threaten the achievements of modern medicine. e extracts of the plant
sources are rich in phytochemicals and they are proven to have promising bioactivities. erefore, searching for new natural
inhibitors is felt to be paramount to nd broader range and novel products for the treatment of cancers with minimal side
e ects. In the current study,
Ziziphus spina-christi
(leaves),
Ziziphus spina-christi
(leaves),
Asafoetida
(resin),
Ajwa Medina
(seeds),
Liquorice Root Powder
(roots)
chamomile ower
(leaves),
Bulk Herbs yme
(leaves) and
marigold owers calendula
(leaves) were collected from Saudi Arabia and United Kingdom in 2017. e dried plant samples were macerated and extracted
using methanol. e resulting crude extracts were tested for their anti-proliferative activity against Hep G2 (hepatocellular
carcinoma) cancer cell line using MTT assay. e total crude extracts of all the tested samples showed more than 70% cytotoxic
activity while,
Asafoetida crude
showed 98%, cytotoxic activity at 50 g/mL concentration. To identify the phytochemicals
present in the active extracts of these plants, chemical pro ling using GCMS and LC-HRESIMS are underway.
Majed90765@hotmail.com